QOW 524

Author: Anila B. Elliott, MD - University of Michigan - C.S. Mott Children’s Hospital

An 8-year-old female with pulmonary hypertension treated with sildenafil and ambrisentan is found to have a mean pulmonary artery pressure (mPAP) of 65mmHg and PVRI of 12.2 Woods Units (WU) on cardiac catheterization. Given these findings, she is being initiated on Treprostinil (Remodulin) subcutaneous infusion.

Which is of the following biologic pathways represents the CORRECT mechanism of action for treprostinil?

A. Nitric oxide -> guanylate cyclase -> cGMP -> vasodilation

B. Inhibition of endothelin -> decreased intracellular calcium -> vasodilation

C. Prostacyclin -> activation of adenylate cyclase -> increase cAMP -> vasodilation

Correct! Wrong!

Question of the Week 524